Scleroderma Information » Scleroderma » Break in Raynauds Research
Question:
This is really interesting and relevant. I have one swollen, throbbing finger that sounds like it could be helped by this treatment. My next appointment with my Rheumy is in November, I am going to see if she has heard of this Research. Thank you, Sherry. Susan – Hide quoted text — Show quoted text -McStyx wrote: > >Subject: Break in Raynauds Research > >From: surviv…@aol.com (Sherry Messick) > >After studying 15 people with scleroderma, Dr. Freedman’s research team > >confirmed that Raynaud’s episodes could be blocked (when physiologically > >provoked in a laboratory setting) by administering L-arginine or sodium > >nitroprusside, both of which are involved in NO production. > I have been taking L-arginine since April upon the recommendation of the doctor > who did some sympathetic nerve blocks to get blood flowing to my feet. On me, > Raynaud’s aggressively attacks my feet and only mildly affects my hands. The > nerve blocks got me walking again and eventually even the ulcers healed. I have > continued to progress and do not know how much is attributable to the long term > effects of the treatment or to L-arginine. Anyway, I am sold on the stuff. My > toes suffer far fewer purple episodes than ever before. > I showed this article to my rheumatologist and he asked me to see if I could > find the abstract for him. I did a cursory search of the Internet to see what I > could find and came up with nothing. This is not surprising, I am no ace at > this searching business. Since my next appointment is several months off, I > have done something I am much more proficient at, I have procrastinated. > Would some of you Internet whizzes out there please help me find the abstract? > All help will be appreciated. > BTW, L-arginine is a product found in most health food stores. I take 1000 mg a > day. > Thanks, > Peggy
Response:
WOW! Thanks so much, Sherry, for posting this. I will definitely ask my doc about it. Fall/Winter/early Spring is no picnic in Cleveland with Raynaud’s, but this really sounds encouraging. Thanks again! Tracy "if you’re on thin ice you may as well dance…"
Response:
You are welcome Tracy. Yes I can relate to your comments about winters not being fun. I just dread to see them coming. I am so bound to the house in the winter. In the summer at least I can go outside and sit and enjoy the breeze russling in the trees or the birds eating from our bird feeder or just to feel the sun on my face. In the winter I just see the world from a window. Whether that window is from my home or car it is how I see the world during those months. Sherry Messick Visit Surviving Scleroderma http://SclerodermaSupport.com The Scleroderma & Autoimmune Digest Email Support List (Subscribe Today) http://SclerodermaSupport.com/digest "We are all Beacons of Light for each other" Oprah Winfrey
Response:
Peggy how are you doing? Have you gotten any more e-mail from the son who had the mother in Ocean Springs Mississippi? My fingers arent working so great tonight so sorry if I make any type-os. I am trying my best, plus this "illegal fuction" sign keeps popping up for reasons I dont understand. Please call me 334/955-6500 so we can get together next week, please. Colleen – Hide quoted text — Show quoted text -Sir Lafsalot wrote: > mPeggy, > When I saw that I was laughing so hard! Yeah, she’s a whiz, all right! > <still LOL snicker snort!> > — > "Barefootin’, rootin’ tootin’ Jessie Jaimes: Soodoh-intelekchule Queen > of d’Nile…" > — > McStyx wrote: > > Amie, > > Thanks for the "whiz" work. That is just what I needed. > > Peggy
Response:
Amie, Thanks for the "whiz" work. That is just what I needed. Peggy
Response:
Peggy, When I saw that I was laughing so hard! Yeah, she’s a whiz, all right! <still LOL snicker snort!> — "Barefootin’, rootin’ tootin’ Jessie Jaimes: Soodoh-intelekchule Queen of d’Nile…" — – Hide quoted text — Show quoted text -McStyx wrote: > Amie, > Thanks for the "whiz" work. That is just what I needed. > Peggy
Response:
>Sherry I have been thinking all of this time that you saw life through your >computer monitor, LOL.
LOL I hadn’t thought of that. LOL. Sherry Messick Visit Surviving Scleroderma http://SclerodermaSupport.com The Scleroderma & Autoimmune Digest Email Support List (Subscribe Today) http://SclerodermaSupport.com/digest "We are all Beacons of Light for each other" Oprah Winfrey
Response:
Sherry I have been thinking all of this time that you saw life through your computer monitor, LOL. Smiles 
Apple Annie ***To reply remove "nospam" from my address*** My favorite scleroderma and arthritis sites are…. http://sclerodermasupport.com http://ihavescleroderma.com http://www.toad.net/~dreichard/ http://arthritisnet.com
Response:
McStyx wrote in message <19991026145536.14506.00001…@ng-cr1.aol.com>… >Would some of you Internet whizzes out there please help me find the
abstract? I took a whiz on the internet and found this summary: Lancet 1999 Aug 28;354(9180):739 Acute effect of nitric oxide on Raynaud’s phenomenon in scleroderma. Freedman RR, Girgis R, Mayes MD Intra-arterial infusions of L-arginine and sodium nitroprusside significantly decreased the occurrence of laboratory-induced Raynaud’s phenomenon in scleroderma patients. Raising the concentration of nitric oxide may be of therapeutic value in this population. Publication Types: Clinical trial Letter Randomized controlled trial PMID: 10475187, UI: 99402172 Online the full report can be ordered from Medline at PubMed http://www.ncbi.nlm.nih.gov/PubMed/ or I’m sure your doc knows how to get ahold of it from this info. Note, this says INFUSION of l-arginine, not pills.
Response:
>Subject: Break in Raynauds Research >From: surviv…@aol.com (Sherry Messick) >After studying 15 people with scleroderma, Dr. Freedman’s research team >confirmed that Raynaud’s episodes could be blocked (when physiologically >provoked in a laboratory setting) by administering L-arginine or sodium >nitroprusside, both of which are involved in NO production.
I have been taking L-arginine since April upon the recommendation of the doctor who did some sympathetic nerve blocks to get blood flowing to my feet. On me, Raynaud’s aggressively attacks my feet and only mildly affects my hands. The nerve blocks got me walking again and eventually even the ulcers healed. I have continued to progress and do not know how much is attributable to the long term effects of the treatment or to L-arginine. Anyway, I am sold on the stuff. My toes suffer far fewer purple episodes than ever before. I showed this article to my rheumatologist and he asked me to see if I could find the abstract for him. I did a cursory search of the Internet to see what I could find and came up with nothing. This is not surprising, I am no ace at this searching business. Since my next appointment is several months off, I have done something I am much more proficient at, I have procrastinated. Would some of you Internet whizzes out there please help me find the abstract? All help will be appreciated. BTW, L-arginine is a product found in most health food stores. I take 1000 mg a day. Thanks, Peggy
Response:
Good Luck Susan. Keep us posted on what you find out. Sherry Messick Visit Surviving Scleroderma http://SclerodermaSupport.com The Scleroderma & Autoimmune Digest Email Support List (Subscribe Today) http://SclerodermaSupport.com/digest "We are all Beacons of Light for each other" Oprah Winfrey
Response:
Wayne State University Researcher Reports: Nitric Oxide Blocks Raynaud’s Incidents in Scleroderma Patients DETROIT, Aug. 30 /PRNewswire/ — The tingling and pain associated with Raynaud’s syndrome (the condition that causes interrupted blood supply to the fingers and toes) can be blocked by increasing the concentration of nitric oxide in the blood. This finding is reported by Wayne State University’s Dr. Robert Freedman in the August 28 issue of The Lancet. Robert Freedman, PhD, professor of psychiatry and behavioral neurosciences at the Wayne State University (WSU) School of Medicine, tested his suspicion that the nitric oxide (NO) pathway was involved in Raynaud’s attacks suffered by patients with scleroderma. Scleroderma, a disease of the immune system, causes the skin on the hands and feet to "harden" or become tight and stiff due to an overgrowth of collagen. Most patients with scleroderma also experience episodes of Raynaud’s, which temporarily stops circulation and causes severe redness, burning, and possible permanent tissue damage. After studying 15 people with scleroderma, Dr. Freedman’s research team confirmed that Raynaud’s episodes could be blocked (when physiologically provoked in a laboratory setting) by administering L-arginine or sodium nitroprusside, both of which are involved in NO production. "These findings suggest that elevated levels of nitric oxide may have therapeutic value against episodes of Raynaud’s," said Dr. Freedman. Co-authors on the study are Dr. Reda Girgis, assistant professor of internal medicine, and Dr. Maureen Mayes, WSU professor and director of the Scleroderma Research and Treatment Unit. This research team has been conducting nationally-funded research on Raynaud’s disease for decades. In the early 1990s, they developed a procedure that helps Raynaud’s sufferers use biofeedback to reduce the frequency of painful symptoms by as much as 92 percent. "In the past, there was no drug available to target the peripheral blood vessels involved in Raynaud’s," said Dr. Freedman. "We have long suspected that the vascular endothelial function was impaired; but it wasn’t until recently that we introduced nitric oxide as an intervening agent. Now, we can offer NO as a therapeutic benefit for patients who suffer from progressive Raynaud’s syndrome." Patients are currently being recruited for related research studies. For more information, please call Wayne State University’s behavioral medicine laboratory at 313-577-7510 or 313-577-0313. The Wayne State University School of Medicine is Detroit’s only medical school and it is the largest single-campus medical school in the country. SOURCE Wayne State University – School of Medicine CO: Wayne State University – School of Medicine ST: Michigan IN: MTC EDU SU: 08/30/99 11:32 EDT http://www.prnewswire.com Sherry Messick Visit Surviving Scleroderma http://SclerodermaSupport.com The Scleroderma & Autoimmune Digest Email Support List (Subscribe Today) http://SclerodermaSupport.com/digest "We are all Beacons of Light for each other" Oprah Winfrey
no comment untill now