Scleroderma Information » Scleroderma » Silicone mammary implants and connective tissue disease.
Question:
Title: Silicone mammary implants and connective tissue disease. Title Abreviation: Scand J Plast Reconstr Surg Hand Surg Date of Pub: 1993 Dec Author: Elberg JJ; Kjoller KH; Krag C; Issue/Part/Supplement: 4 Volume Issue: 27 Pagination: 243-8 MESH Headings: Adult; Connective Tissue Diseases (*ET); Female; Human; Implants, Artificial (*AE); Mammaplasty (*); Middle Age; Raynaud’s Disease (ET); Scleroderma, Systemic (ET); Silicones (*AE); Synovitis (ET); -RN-; Journal Title Code: UDN Publication Type: JOURNAL ARTICLE Date of Entry: 940516N Entry Month: 9407 Country: SWEDEN Index Priority: 2 Language: Eng Unique Identifier: 94212088 Unique Identifier: 94212088 ISSN: 0284-4311 Abstract: The American Food and Drug Administration recently restricted the use of silicone gel-filled mammary implants for breast augmentations and reconstructions because a number of case reports had suggested that there was an association between silicone and connective tissue disease. We have found 36 such case reports published since 1982. Systemic sclerosis is the most common reported diagnosis (n = 15). Implants were removed from 15 patients, in nine of whom symptoms improved. The mechanism behind the postulated relationship is obscure, and most authors focused on an auto-immune-like response to silicone, which acts directly as a hapten or as an adjuvant. We found no conclusive evidence to implicate silicone mammary implants in connective tissue diseases. We do, however, recommend removal of implants from patients with severe connective tissue diseases. Patients with symptoms or active connective tissue disease should not be considered for silicone implants. Address: Department of Plastic Surgery, Copenhagen University Hospital, Herlev, Denmark. Number of References: 32
Response:
We found no conclusive evidence to implicate silicone mammary implants in connective tissue diseases. We do, however, recommend removal of implants from patients with severe connective tissue diseases.
Sounds like a paper written by a committee. The second statement does not follow from the first and in fact appears to repudiate it. Ed Ed Uthman, MD <http://www.neosoft.com/~uthman/ corpore servit." Pathologist -Seneca Houston/Richmond, Texas, USA
Response:
Title: Silicone mammary implants and connective tissue disease. Title Abreviation: Scand J Plast Reconstr Surg Hand Surg Date of Pub: 1993 Dec Author: Elberg JJ; Kjoller KH; Krag C; Issue/Part/Supplement: 4 Volume Issue: 27 Pagination: 243-8 MESH Headings: Adult; Connective Tissue Diseases (*ET); Female; Human; Implants, Artificial (*AE); Mammaplasty (*); Middle Age; Raynaud’s Disease (ET); Scleroderma, Systemic (ET); Silicones (*AE); Synovitis (ET); -RN-; Journal Title Code: UDN Publication Type: JOURNAL ARTICLE Date of Entry: 940516N Entry Month: 9407 Country: SWEDEN Index Priority: 2 Language: Eng Unique Identifier: 94212088 Unique Identifier: 94212088 ISSN: 0284-4311 Abstract: The American Food and Drug Administration recently restricted the use of silicone gel-filled mammary implants for breast augmentations and reconstructions because a number of case reports had suggested that there was an association between silicone and connective tissue disease. We have found 36 such case reports published since 1982. Systemic sclerosis is the most common reported diagnosis (n = 15). Implants were removed from 15 patients, in nine of whom symptoms improved. The mechanism behind the postulated relationship is obscure, and most authors focused on an auto-immune-like response to silicone, which acts directly as a hapten or as an adjuvant. We found no conclusive evidence to implicate silicone mammary implants in connective tissue diseases. We do, however, recommend removal of implants from patients with severe connective tissue diseases. Patients with symptoms or active connective tissue disease should not be considered for silicone implants. Address: Department of Plastic Surgery, Copenhagen University Hospital, Herlev, Denmark. Number of References: 32
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